• Turk J Med Sci · Jan 2024

    Antiobesity and antidyslipidemic properties of Clitoria ternatea petals aqueous extract against rats induced by high-fat diet.

    • I Gede Aswin Parisya Sasmana, Desak Made Wihandani, I Gede Krisna Arim Sadeva, Wilson Halim, Putu Putri Agustini, Lalita Samala, I Gusti Ngurah Agung Surya Pratama, Lidiya Nuraliza Rachmawati, Aizar Vesa Prasetyo, and Ni Komang Ayu Amanda Setiari Jaya.
    • Undergraduate Student, Faculty of Medicine, Udayana University, Denpasar, Indonesia.
    • Turk J Med Sci. 2024 Jan 1; 54 (2): 401410401-410.

    Background/AimObesity is a chronic metabolic disease involving dysregulation of fat metabolism that affects 13% of the world's population. Obesity has been linked to dyslipidemia with a lot of complication, including stroke, chronic kidney disease, fatty liver disease, and so on. One of the natural resources that have several potential effects including anticholesterol, antiobesity, and antidyslipidemia is the butterfly pea (Clitoria ternatea/CT). CT's petal has been found to contain high levels of anthocyanins and tannins that can inhibit the biosynthesis of cholesterol and lipid. This study aims to investigate the antiobesity and antidyslipidemic effects of Clitoria ternatea extract (CTE).Materials And MethodsThe CTE was obtained through the aqueous extract method and then was investigated using spectrophotometry to determine anthocyanin and tannin content. The effect of CTE against a high-fat diet (HFD)-induced rat model was measured by weight and obesity index, lipid profile (total cholesterol (TC), triglycerides (TG), and HDL-C), and histopathology analysis.ResultsCTE showed total anthocyanin and tannin content of 78.0943 mg/100 g and 1424.90 mg/100 g, respectively. The data analysis also showed significantly different within groups (p < 0,05), especially between HFD and HFD + CT750 groups on the cholesterol (MD 111.12 mg/dL; 95% CI (99.57 to 122.67); p < 0.001), LDL (MD; 76.38 mg/dL; 95% CI (56.77 to 96.00); p < 0.001), VLDL (MD 0.37 mg/dL; 95% CI (0.18 to 0.57); p < 0.001), body weight (MD: 56.20 g; 95% CI (13.89 to 98.51); p = 0.012); and thickening of tunica layer in the thoracic aorta (MD 22.76 μm; 95% CI (20.11 to 24.4); p < 0.001).ConclusionThis study shows that Clitoria ternatea petals aqueous extract promotes amelioration of the lipid profile, body weight, and tunica thickness in rats with the high-fat diet.© TÜBİTAK.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…