• Internal medicine · Jul 2024

    A Man with Primary Hyperchylomicronemia with Triglyceride Levels Exceeding 11,000 mg/dL was Well Controlled by Pemafibrate Combined with Dietary Therapy: A Case Report.

    • Hiroyuki Ueda, Ryohei Mineo, Takuya Sugiyama, Masahiro Koseki, Yoshito Itoh, Ryuya Iwamoto, Sachiko Tamba, Koji Yamamoto, Yuya Yamada, Hisatoyo Hiraoka, and Yuji Matsuzawa.
    • Department of Endocrinology and Metabolism, Sumitomo Hospital, Japan.
    • Intern. Med. 2024 Jul 25.

    AbstractA 50-year-old man with a triglyceride (TG) level of 11,397 mg/dL was admitted to our hospital. He consumed a high-fat and high-carbohydrate diet as well as more than 100 g of alcohol per day. He had type 2 diabetes and obesity and had previously suffered from severe acute pancreatitis twice. A genetic analysis revealed compound heterozygous mutations in APOA5 (c.56C>G and c.553G>T). In addition to low-fat meals and alcohol cessation, administration of pemafibrate lowered his triglyceride levels to <150 mg/dL.

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