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- Takeya Edagawa, Hiroyoshi Iwagami, Takuji Akamatsu, Shogo Nakano, Midori Wakita, Takafumi Konishi, Yasuki Nakatani, Yoshito Uenoyama, and Yukitaka Yamashita.
- Departments of Gastroenterology and Hepatology, Japanese Red Cross Wakayama Medical Center.
- Intern. Med. 2024 Jul 25.
AbstractMethotrexate may cause methotrexate-associated lymphoproliferative disorder (MTX-LPD); however, this disease is uncommon in the gastrointestinal tract. We examined six patients with MTX-LPD in the gastrointestinal tract at our hospital. All of the lesions were ulcerative. Four cases regressed spontaneously, all of which were positive for Epstein-Barr virus-encoded small RNA by in situ hybridization. Two patients who did not regress were negative for Epstein-Barr virus RNA, one of whom received chemotherapy, and one underwent surgery. The prognosis of this disease is considered to be good. MTX-LPD should considered when ulcerative lesions are observed during endoscopy in patients receiving MTX.
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