• Internal medicine journal · Sep 2024

    Review

    ANZTCT practice statement: sinusoidal obstruction syndrome/veno-occlusive disease diagnosis and management.

    • Shaun Fleming, Ashleigh P Scott, John Coutsouvelis, Chris Fraser, Ashish Bajel, Adam Nelson, Rachel Conyers, Ashley McEwan, David Yeung, Victoria Campion, Lochie Teague, Matthew McGuire, Edward Morris, Melissa Gabriel, Rebecca Wayte, Genevieve Douglas, Nicole Chien, and Nada Hamad.
    • Clinical Haematology, Alfred Hospital and Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia.
    • Intern Med J. 2024 Sep 1; 54 (9): 154815561548-1556.

    AbstractSinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a life-threatening complication which can develop after haemopoietic stem cell transplantation (HSCT) and some antibody-drug conjugates. Several SOS/VOD diagnostic and management guidelines exist, with the most recent and refined being the European Society for Blood and Marrow Transplantation adult and paediatric guidelines. Timely diagnosis and effective management (including the availability of therapeutic options) significantly contribute to improved patient outcomes. In Australia and New Zealand, there is variability in clinical practice and access to SOS/VOD therapies. This review aims to summarise the current evidence for SOS/VOD diagnosis, prevention and treatment and to provide recommendations for SOS/VOD in the context of contemporary Australasian HSCT clinical practice.© 2024 The Author(s). Internal Medicine Journal published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Physicians.

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