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- Hiroto Yanagisawa, Keita Mishima, Yaya Yamanouchi, Yusuke Ueda, Takahiro Yamano, Haruka Iwao-Kawanami, Tomoyuki Sakai, Takafumi Kawanami, Kazunori Yamada, Mitsuhiro Kawano, Shuichi Mizuta, Toshihiro Fukushima, and Yasufumi Masaki.
- Department of Hematology & Immunology, Kanazawa Medical University, Japan.
- Intern. Med. 2024 Aug 8.
AbstractA 77-year-old man presented with right inguinal lymphadenopathy and swollen parotid and submandibular glands bilaterally. Histopathology revealed germinal center B-cell type diffuse large B-cell lymphoma (DLBCL) in the inguinal lymph node. Lymphocyte and plasma cell infiltration in the submandibular gland with elevated serum IgG4 levels (13 g/L) prompted a diagnosis of IgG4-related disease (IgG4-RD). Systemic chemotherapy for DLBCL led to shrinkage of the lymph nodes and disappearance of the submandibular gland swelling, as confirmed by fluorodeoxyglucose-positron emission tomography/computed tomography. Although concomitant IgG4-RD and lymphoma have been reported, their simultaneous diagnosis is rare; therefore, a biopsy of all involved organs is crucial in cases with unusual organ involvement.
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