• Internal medicine · Aug 2024

    Successful Maintenance Therapy with Intravenous Immunoglobulin to Reduce Relapse Attacks and Steroid Dose in a Patient with Refractory Myelin Oligodendrocyte Glycoprotein Antibody-positive Optic Neuritis.

    • Yui Kamijo, Maho Usuda, Atsuhiro Matsuno, Nagaaki Katoh, Yuki Morita, Fuyuhiko Tamaru, Hirotsugu Kasamatsu, and Yoshiki Sekijima.
    • Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.
    • Intern. Med. 2024 Aug 8.

    AbstractA 25-year-old Japanese man developed visual disturbance with eye pain and was diagnosed with optic neuritis associated with anti-myelin oligodendrocyte glycoprotein antibodies. His symptoms improved temporarily after steroid therapy but chronically relapsed many times after tapering the steroid dose. He became highly steroid-dependent and was referred to our department for reconsideration of the treatment strategy. Maintenance intravenous immunoglobulin (IVIg) therapy successfully decreased the annual recurrence rate from 1.15 to 0.27 times/year and the maintenance dose of oral prednisolone from 35 to 5 mg/day. Maintenance IVIg therapy is a promising option for preventing disease relapse in such cases.

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