• Patricia Albertini Orioli, Cintia Johnston, Juliana Zoboli Del Bigio, KrebsVera Lucia JornadaVLJDepartment of Pediatrics, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brasil., Mariana Pissolato, Maria Augusta Bento Cicaroni Gibelli, Orlei Ribeiro De Araujo, FranciscoRossana Pulcineli VieiraRPVDepartment of Obstetrics, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brasil., and Werther Brunow De Carvalho.
• Department of Pediatrics, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brasil. Electronic address: patricia.orioli@hc.fm.usp.br.
• Clinics (Sao Paulo). 2024 Jan 1; 79: 100460100460.

ObjectiveThis study aimed to evaluate the Neuropsychomotor Development (NPMD) of newborns exposed to SARS-CoV-2 in the perinatal period using the Bayley III scale at 6 months of age.MethodsChildcare appointments were scheduled for the included newborns in the study. During the 6-month consultation, the Screening Test for Bayley III Scale and, based on it, children were classified as "low risk", "moderate risk" or "high risk" in the domains: of cognitive, receptive language, expressive language, fine motor, and gross motor. Those classified as "moderate risk"; or "high risk" received guidance about NPMD stimuli and were instructed to maintain follow-up.ResultsOnly 13 (37.1 %) of the newborns were classified as low risk in receptive language and 18 (51.4 %) in gross motor skills, with the domains most affected. Prematurity was a risk for cognitive incompetence (moderate risk/high-risk classification) (coefficient: 1.89, Odds Ratio = 6.7, 95 % CI 1.3‒35, p = 0.02). Lower birth weight that 2.500g had a similar effect on cognitive incompetence (coefficient: 1.9, Odds Ratio = 6.2, 95 % CI 1.2‒32.2, p = 0.02). Exclusive breastfeeding at hospital discharge (n = 8) was protective for incompetence (high risk/moderate risk) in the language domain (coefficient -2.14, OR = 0.12, 95 % CI 0.02‒0.71, p = 0.02).ConclusionsThe children included in the study must be monitored and their development monitored in order to clarify whether there is a relationship between the delay in NPMD and perinatal exposure to COVID-19, as delays were observed in these preliminary results.Copyright © 2024 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.

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