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- Pierre-Edouard Debureaux, Nathalie Parquet, Anne C Brignier, Dikelele Elessa, Virginie Lemiale, Virginie Siguret, Pierre-Antoine Quintard, Stéphanie Harel, Bruno Royer, Bertrand Arnulf, and Alexis Talbot.
- Service immuno-hématologie, hôpital Saint Louis, Paris, France; Université Paris Cité, institut de recherche Saint-Louis, Inserm U1160, Paris, France.
- Rev Med Interne. 2024 Aug 7.
AbstractSeric hyperviscosity syndrome is a medical emergency linked to hyperproteinemia. The clinical diagnosis hinges on a triad of symptoms: mucosal hemorrhages, visual disturbances, and neurological disorders, observed in the most severe cases. Diagnosis is swiftly confirmed through an urgent fundoscopic examination. Therapeutic plasma exchange is the primary treatment for severe cases or following confirmation by fundoscopy. Laboratory tests predominantly identify the syndrome's etiology, with Waldenström's macroglobulinemia (characterized by a marked IgM peak) being the most common cause, followed by multiple myeloma and cryoglobulinemias. To prevent recurrence, targeted treatment of the underlying cause is implemented following plasma exchange sessions.Copyright © 2024 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.
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