• Lancet · Aug 2024

    Review

    New promises and challenges in the treatment of advanced non-small-cell lung cancer.

    • May-Lucie Meyer, Bailey G Fitzgerald, Luis Paz-Ares, Federico Cappuzzo, Pasi A Jänne, Solange Peters, and Fred R Hirsch.
    • Center for Thoracic Oncology, Tisch Cancer Institute, Mount Sinai Health System, New York City, NY, USA.
    • Lancet. 2024 Aug 24; 404 (10454): 803822803-822.

    AbstractTargeted therapies and immunotherapies have radically improved treatment for advanced non-small-cell lung cancer (NSCLC). Tyrosine kinase inhibitors targeting oncogenic driver mutations continue to evolve over multiple generations to enhance effectiveness and tackle drug resistance. Immune checkpoint inhibitors remain integral for the treatment of NSCLCs that do not have specific actionable genetic mutations. Antibody-drug conjugates and bispecific antibodies are being integrated into treatment guidelines, and emerging therapies include T-cell engagers, cellular therapies, cancer vaccines, and external devices. Despite these advances, challenges remain in identifying predictive biomarkers to individually tailor treatments, abrogate resistance, reduce costs, and ensure optimal cancer treatment accessibility.Copyright © 2024 Elsevier Ltd. All rights reserved, including those for text and data mining, AI training, and similar technologies.

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