• Kehinde Alare, Abdulbasit Muili, Samson Afolabi, Busayo Adetunji, Nicholas Aderinto, and Ebtesam Abdulla.
• Department of Medicine, Ladoke Akintola University of Technology, Ogbomoso, Nigeria; Bowers Neurosurgical Frailty and Outcomes Data Science Lab, Sandy, Texas, USA. Electronic address: alarekehindepaul@gmail.com.
• World Neurosurg. 2024 Oct 1; 190: 451462.e13451-462.e13.

BackgroundFrailty refers to a state of weakness that can arise due to age or illnesses, and frailty predisposes individuals to several adverse health outcomes. This has been postulated to prognosticate the outcome of various surgeries, including surgeries for primary brain tumors; however, no meta-analysis has validated this finding.MethodsWe conducted a systematic review and meta-analysis to investigate the prognostic utility of frailty for the outcome of primary brain tumor surgery. We performed a systematic search of the PubMed, EMBASE, and SCOPUS databases for studies investigating the ability of frailty to predict the outcome of primary brain tumor surgery.ResultsMeta-analysis of the information provided in the thirteen studies that made up our sample. Hospital length of stay (effect size 0.94; 95% confidence interval [CI]: 0.37, 1.51; p: 0.00), postoperative complications (effect size 10.31; 95% CI: -5.88, 26.86; p: 0.21), readmission (effect size 0.82; 95% CI: 0.23, 1.41; p: 0.01), nonroutine discharge (effect size 1.07; 95% CI: 0.48, 1.65; 0.00), postoperative mortality (effect size 1.48; 95% CI: 0.81, 2.02; p: 0.00), and overall survival (effect size 1.53; 95% CI: 0.29, 2.76; p: 0.02).ConclusionsThis study showed little correlation with postoperative mortality, readmission, nonroutine discharge, length of hospital stay, or overall survival, and fragility had less significance in these areas but showed no statistical significance in predicting postoperative complications following surgery for primary brain tumors.Copyright © 2024 Elsevier Inc. All rights reserved.

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