• Eur J Anaesthesiol · Nov 2024

    Meta Analysis

    Intravenous lidocaine for postoperative analgesia management in paediatrics: A systematic review with meta-analysis of published studies.

    • Pierre Pardessus, Maud Loiselle, Kelly Brouns, Anne-Laure Horlin, Beatrice Bruneau, Yara Maroun, Martin Lagarde, Maxime Deliere, Florence Julien-Marsollier, and Souhayl Dahmani.
    • From the University of Paris-Cité (PP, ML, KB, A-LH, BB, YM, ML, MD, FJ-M, SD), Department of Anaesthesia and Intensive Care (PP, ML, KB, A-LH, BB, YM, ML, MD, FJ-M, SD), FHU I2D2, Robert Debré University Hospital, Paris, France (PP, ML, KB, A-LH, BB, YM, ML, MD, FJ-M, SD).
    • Eur J Anaesthesiol. 2024 Nov 1; 41 (11): 856864856-864.

    BackgroundThe administration of intravenous lidocaine during the peri-operative period may improve pain management after paediatric surgery.ObjectiveTo explore the decrease in postoperative pain intensity and opioid consumption associated with peri-operative lidocaine administration in the paediatric population.DesignA systematic review with meta-analysis of randomised controlled trials and a Grading of Recommendations Assessment, Development and Evaluation (GRADE) analysis.Data SourcesExtensive literature review.Eligibility CriteriaThis study includes clinical trials conducted during surgery that examined the effect of intravenous lidocaine compared with placebo on postoperative pain management.ResultsLidocaine administration decreased pain intensity in PACU (standardised mean difference (SMD) = -1.89 [-3.75, -0.03], I2  = 97%, P of I2  < 0.001) and on postoperative day 1 (SMD = -2.02 [-3.37, -0.66], I2  = 96%, P of I2  < 0.001, number of studies = 5). Lidocaine was associated with a decrease in opioid consumption on postoperative day 1 (SMD = -1.2 [-2.19, -0.2], I2  = 93%, P of I2  < 0.001) but not on postoperative day 2 (SMD = -1.73 [-3.9, 0.44], I2  = 96%, P of I2  < 0.001). GRADE analyses resulted in low-quality results. Subgroup analyses revealed that pain intensity in PACU and opioid consumption on postoperative day 1 decreased when lidocaine was administered during both the intra-operative and postoperative periods.ConclusionsThe use of lidocaine is associated with improved pain management. However, further studies are needed to increase the level of evidence and determine the optimal administration regimen for pain management.Copyright © 2024 European Society of Anaesthesiology and Intensive Care. Unauthorized reproduction of this article is prohibited.

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