• David S Jevotovsky, Harman Chopra, Daniel J Pak, Shravani Durbhakula, Alexander Shustorovich, Tanya Juneja, Mustafa Y Broachwala, Tariq AlFarra, Caroline Silver, Greg Kreitzer, Philip Oreoluwa, Braden B Weissman, Abraham AlFarra, Brian G Mayrsohn, Vwaire Orhurhu, Trent Emerick, Timothy Furnish, and Joel P Castellanos.
• Physical Medicine & Rehabilitation, New York University Grossman School of Medicine, New York, New York, USA.
• Reg Anesth Pain Med. 2024 Aug 8.

Background/ImportanceChronic pain affects many people globally, requiring alternative management strategies. Psilocybin is gaining attention for its potential in chronic pain management despite being classified as Schedule I.ObjectiveThis systematic review critically evaluates the evidence for psilocybin, a Schedule I substance, in the treatment of chronic pain. The exact purpose of the review is to assess the impact of psilocybin on chronic pain relief, focusing on dosing protocols, treated conditions, and patient outcomes.Evidence ReviewA comprehensive review of PubMed, CINAHL, Web of Science, Cochrane Library, and EMBASE was conducted up to January 2024. Eligibility criteria included studies evaluating psilocybin for chronic pain management. The risk of bias was assessed using the MASTER (MethodologicAl STandards for Epidemiological Research) scale, and the strength of evidence was graded using GRADE (Grading of Recommendations, Assessment, Development, and Evaluation).FindingsThe review identified 28 relevant studies focusing on dosing, treated conditions, and outcomes. The majority of the included studies (76.2%) were of low or very low quality. Several studies with moderate-to-low-quality evidence utilized a 0.14 mg/kg dosing protocol. The findings suggest promise for the use of psilocybin in chronic pain relief, though the quality of evidence is generally low.ConclusionsThe current research shows potential for psilocybin as a treatment option for chronic pain relief. However, methodological issues and a lack of high-quality evidence underscore the need for further investigations with standardized protocols. Despite these limitations, the potential for psilocybin in chronic pain management is encouraging.Prospero Registration NumberCRD42023493823.© American Society of Regional Anesthesia & Pain Medicine 2024. No commercial re-use. See rights and permissions. Published by BMJ.

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