• Raghad Alhajaji, Mayada Mohammad Samkari, Mona A Althobaiti, Bashaer Ruddah Al-Ahmadi, Alaa Mohammed Bugis, Amjad Mohammed Bugis, Fatimah Yaseen Sabbagh, Somaya A Althobaiti, Amro S Bukari, Safenaz Meshal Alqurashi, Hana Abdullah Mshrai, and Omar Ahmed Abdelwahab.
• From the Department of Public Health, Makkah Branch of the Ministry of Health, Makkah, Saudi Arabia.
• Ann Saudi Med. 2024 Jul 1; 44 (4): 272287272-287.

BackgroundSpontaneous bacterial peritonitis (SBP) represents a critical and potentially lethal condition that typically develops in individuals with liver cirrhosis. This meta-analysis aimed to assess diabetes mellitus (DM) as a risk factor for SBP in liver cirrhotic patients.MethodsFollowing PRISMA guidelines, fifteen studies were included, for a total of 76 815 patients. The risk of bias was assessed using the Newcastle-Ottawa scale (NOS). We represented the results as risk ratios (RR) with the corresponding 95% confidence intervals (CI) using RevMan software. Additionally, we pooled the hazard ratios (HR) for developing SBP in patients with DM from the included studies.ResultsThe meta-analysis shows a significantly increased risk of SBP in cirrhotic patients with DM (HR: 1.26; 95% CI [1.05-1.51], P=.01; HR: 1.70; 95% CI [1.32-2.18], P<.001).ConclusionsThe study signifies that DM is an independent risk factor for SBP, emphasizing the need for targeted preventive measures in this specific population.

15 keywords...

hide…