• Giuseppina Tiziana Russo, Annalisa Giandalia, Giuseppe Lucisano, Maria Chiara Rossi, Pamela Piscitelli, Roberto Pontremoli, Francesca Viazzi, Alberto Rocca, Valeria Manicardi, Graziano Di Cianni, Riccardo Candido, Antonio Nicolucci, Salvatore De Cosmo, and AMD Annals Study Group.
• Department of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy. Electronic address: giuseppina.russo@unime.it.
• Eur. J. Intern. Med. 2024 Aug 10.

BackgroundDiabetic kidney disease is the most common cause of end-stage kidney disease (ESKD) in the western world. Rapid estimated glomerular filtration rate (eGFR) decline is an independent predictor of ESKD and death in the general population and in subjects with type 2 diabetes mellitus (T2D).AimWe investigated in a large sample of subjects with newly diagnosed T2D the prevalence and clinical determinants of fast eGFR decline, taking advantage from the dataset of the Associazione Medici Diabetologi (AMD) Annals initiative.MethodsThe eGFR trajectories were evaluated by applying a linear mixed model for repeated measures (LMMRM) and rapid eGFR decline defined as an eGFR decline greater than 5 mL/min/1.73 m2 per year at 3 years.ResultsAmong 105,163 (57.7% M) subjects with newly diagnosed T2D, 13,587 (12.9 %) subjects showed a rapid eGFR loss. The independent significant predictors were age, female gender, HbA1c, smoking, high baseline eGFR, albuminuria and retinopathy.ConclusionOur study demonstrates that a significant percentage of newly diagnosed T2D subjects have a rapid eGFR decline. Given the association between dynamic changes in eGFR and the risk of ESKD or death, we suggest to include this variable in the definition of CKD.Copyright © 2024. Published by Elsevier B.V.

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