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- Diane P Calello, Kevin C Osterhoudt, and Fred M Henretig.
- Division of Emergency Medicine and the Poison Control Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. calello@email.chop.edu
- Pediatr Emerg Care. 2006 Jul 1; 22 (7): 523530523-30.
AbstractAntidotal therapy can be lifesaving in the management of poisoned children. Although supportive care is sufficient in many cases, a specific antidote can significantly reduce morbidity and mortality in a number of poisoning scenarios, and so the pediatric emergency medicine practitioner must be familiar with its indications for use, dosage and administration, and contraindications. A number of new antidotes have emerged in recent years. This review discusses the pediatric uses and limitations of intravenous N-acetylcysteine, octreotide, crotaline Fab antivenom, fomepizole, atropine and pralidoxime autoinjectors and provides some brief discussion on newer antidotes for which data is only starting to emerge.
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