• Internal medicine · Aug 2024

    Esophageal and Ileal Ulcers Caused by Hydroxycarbamide: A Case Report and Literature Review.

    • Takumi Inaba, Yu Yamamoto, Kaho Hirayama, Takuma Kobayashi, Naoto Izumi, Hirotsugu Sakamoto, Shuji Hatakeyama, and Masami Matsumura.
    • Division of General Internal Medicine, Jichi Medical University Hospital, Japan.
    • Intern. Med. 2024 Aug 10.

    AbstractHydroxycarbamide, an antimetabolic agent used to treat myeloproliferative disorders, causes side effects, including myelosuppression, skin ulcers, and oral mucositis. Gastrointestinal ulcers are uncommon, and esophageal ulcers have not been previously reported. We present the case of a 74-year-old woman who developed esophageal and ileal ulcers after hydroxycarbamide treatment. Our case and previous reports suggest that hydroxycarbamide can cause ulcers throughout the gastrointestinal tract, which can improve rapidly after discontinuing medication. When new signs and symptoms occur, drug-induced etiologies should be considered as a potential cause. Timely diagnostic treatment with discontinuation of medication is crucial in such cases.

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