• Gonzalo Barge-Caballero, Alicia Freire-Ruaño, Alba González-Rodríguez, Juan M Villa-Fernández, Jorge Pombo-Otero, and María G Crespo-Leiro.
• Unidad de Insuficiencia Cardiaca y Trasplante Cardiaco, Servicio de Cardiología, Complexo Hospitalario Universitario A Coruña, A Coruña, España; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, España. Electronic address: gonzalo.barge.caballero@sergas.es.
• Med Clin (Barc). 2024 Oct 25; 163 (8): e84e88e84-e88.

Introduction And ObjectiveClinical manifestations secondary to amyloid deposition in connective tissue may allow early detection of amyloidosis. We sought to identify the prevalence of connective tissue amyloidosis in patients undergoing orthopedic surgery and evaluate for cardiac involvement.Material And MethodsDescriptive cross-sectional study that included patients >50 years referred for orthopedic surgery at our center. A sample of the affected connective tissue was taken during the intervention to evaluate the presence of amyloid material. Those with confirmed amyloidosis were further evaluated with complementary tests for cardiac involvement.ResultsForty-eight patients were included. Mean age was 65.4 years and 41.7% were women. The most frequent surgery was supraspinatus tendon rupture (50%). Transthyretin amyloid deposits were detected in 2 patients (4.2%). The absence of variants in the protein gene established the diagnosis of ATTRwt in both cases. None of them presented cardiac involvement.ConclusionsIn this study, 4.2% of patients referred for orthopedic surgery presented transthyretin amyloidosis in the affected connective tissue.Copyright © 2024 Elsevier España, S.L.U. All rights reserved.

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