• Zahra Momayez Sanat, Homayoon Vahedi, Reza Malekzadeh, Amir Kasaeian, Negar Mohammadi Ganjaroudi, Alireza Sima, Fariborz Mansour Ghanaei, Mohammadreza Ghadir, Hafez Tirgar Fakheri, Siavosh Nasseri Moghaddam, Sudabeh Alatab, Anahita Sadeghi, Amir Anushiravani, Iradj Maleki, Abbas Yazdanbod, Hassan Vossoughinia, Mohammadreza Seyyedmajidi, Sayed Jalaleddin Naghshbandi, Nadieh Baniasadi, Baran Parhizkar, Saied Matinkhah, Shahsanam Gheibi, Roya-Sadat Hosseini Hemmat Abadi, and Seyedmohamad Valizadeh Toosi.
• Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
• Arch Iran Med. 2024 Jul 1; 27 (7): 350356350-356.

BackgroundUlcerative colitis (UC) is a form of inflammatory bowel disease (IBD) marked by rectal and colon inflammation, leading to relapsing symptoms. Its prevalence is increasing, particularly in developed nations, impacting patients' health. While its exact cause remains unclear, genetic and environmental factors are implicated, elevating the risk of colorectal cancer (CRC). Colectomy, though declining, is still performed in select UC cases, necessitating further study.MethodsWe analyzed data from the Iranian Registry of Crohn's and Colitis (IRCC) to examine UC patients undergoing colectomy. We collected demographic and clinical data from 91 patients, focusing on dysplasia. Statistical analyses assessed dysplasia risk factors.ResultsPatients with dysplasia were older at diagnosis and surgery compared to those without dysplasia. Age emerged as a significant risk factor for dysplasia in UC patients undergoing colectomy. No significant associations were found between dysplasia and other factors.ConclusionAge plays a crucial role in dysplasia risk among UC patients undergoing colectomy. Older age at diagnosis and surgery may indicate a higher risk of dysplasia and CRC. Clinicians should consider age when managing UC patients and implementing screening protocols. Further research with larger samples is needed to confirm these findings.© 2024 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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