• Francesco Corallo, Simona De Salvo, Daniela Floridia, Lilla Bonanno, Nunzio Muscarà, Francesco Cerra, Cecilia Cannistraci, Marcella Di Cara, Viviana Lo Buono, Placido Bramanti, and Silvia Marino.
• IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy.
• Medicine (Baltimore). 2020 Jan 1; 99 (3): e18633e18633.

AbstractPain has a major impact on anxiety and depression levels. The aim of this study is to demonstrate how these symptoms (depression and anxiety) could positively influence the perception of pain after neurostimulation system implantation.We enrolled 100 patients and divided in 2 different groups, by using tests screening such as Beck Depression Inventory (BDI), Hamilton Anxiety Rating Scale (HAM-A), Nursing Rating Scale (NRS): the group with spinal cord stimulation (SCS) and the group with pulsed spinal cord radiofrequency (RFP).We highlighted a significant decrease of scores (BDI, HAM-A, NRS) in each group between T0 (baseline) and T1. Moreover, the intra-group analysis showed a positive significant correlation between NRS and depressive and anxiety symptoms.We assert that the use of alternative methods (SCS and RFP) to the traditional pharmaceutical-surgical treatments, provide the reduction of the algic and anxiety-depressant symptoms, restoring also the perception of psychological well-being.

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