To the Brain and Beyond: Neurological Implications of

J Neurosurg Anesthesiol · Jul 2024

To the Brain and Beyond: Neurological Implications of Glucagon-Like Peptide-1 Receptor Agonists.

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as an increasingly popular class of medications commonly used for glycemic control in patients with type 2 diabetes mellitus and for weight loss. GLP-1 RAs also have potential benefits in patients with various neurological diseases independent of their glucose-modulating effect. In this focused review, we explore animal and clinical evidence evaluating the impact of GLP-1 RAs in common neurological diseases. Our aim is to provide a basis for hypothesis generation for future studies to assess the role that GLP-1 RAs may have on the nervous system, including implications for the perioperative period.

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- Hunter GuevaraLindsay RLRDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, MN., W Brian B Beam, and Jeffrey J Pasternak.
- Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, MN.
- J Neurosurg Anesthesiol. 2024 Jul 31.
AbstractGlucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as an increasingly popular class of medications commonly used for glycemic control in patients with type 2 diabetes mellitus and for weight loss. GLP-1 RAs also have potential benefits in patients with various neurological diseases independent of their glucose-modulating effect. In this focused review, we explore animal and clinical evidence evaluating the impact of GLP-1 RAs in common neurological diseases. Our aim is to provide a basis for hypothesis generation for future studies to assess the role that GLP-1 RAs may have on the nervous system, including implications for the perioperative period.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

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To the Brain and Beyond: Neurological Implications of Glucagon-Like Peptide-1 Receptor Agonists.

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