• Giuliano Testa, Greg J McKenna, Anji Wall, Johanna Bayer, Anthony R Gregg, Ann Marie Warren, Seung Hee S Lee, Eric Martinez, Amar Gupta, Robert Gunby, and Liza Johannesson.
• Department of Surgery, Baylor Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, Texas.
• JAMA. 2024 Sep 10; 332 (10): 817824817-824.

ImportanceUterus transplant in women with absolute uterine-factor infertility offers the possibility of carrying their own pregnancy.ObjectiveTo determine whether uterus transplant is feasible and safe and results in births of healthy infants.Design, Setting, And ParticipantsA case series including 20 participants with uterine-factor infertility and at least 1 functioning ovary who underwent uterus transplant in a large US tertiary care center between September 14, 2016, and August 23, 2019.InterventionThe uterus transplant (from 18 living donors and 2 deceased donors) was surgically placed in an orthotopic position with vascular anastomoses to the external iliac vessels. Participants received immunosuppression until the transplanted uterus was removed following 1 or 2 live births or after graft failure.Main Outcomes And MeasuresUterus graft survival and subsequent live births.ResultsOf 20 participants (median age, 30 years [range, 20-36]; 2 Asian, 1 Black, and 16 White), 14 (70%) had a successful uterus allograft; all 14 recipients gave birth to at least 1 live-born infant. Eleven of 20 recipients had at least 1 complication. Maternal and/or obstetrical complications occurred in 50% of the successful pregnancies, with the most common being gestational hypertension (2 [14%]), cervical insufficiency (2 [14%]), and preterm labor (2 [14%]). Among the 16 live-born infants, there were no congenital malformations. Four of 18 living donors had grade 3 complications.Conclusions And RelevanceUterus transplant was technically feasible and was associated with a high live birth rate following successful graft survival. Adverse events were common, with medical and surgical risks affecting recipients as well as donors. Congenital abnormalities and developmental delays have not occurred to date in the live-born children.Trial RegistrationClinicalTrials.gov Identifier: NCT02656550.

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