• Vet Hum Toxicol · Jun 1996

    Comparative Study

    The effects of verapamil and lidocaine on the duration of propofol and xylazine-ketamine anesthesia in broiler chickens.

    • J D Roder, Y Shen, and S Sangiah.
    • Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater 74078, USA.
    • Vet Hum Toxicol. 1996 Jun 1;38(3):181-3.

    AbstractThe effects of verapamil, a calcium channel blocker, and lidocaine, a sodium channel blocker, administration on the duration of 1 mg propofol/kg i.v. or 5 mg xylazine/kg + 15 mg ketamine/kg i.m. anesthesia were examined in 1 and 6-w-old broiler chickens. The use of 2.5 or 1.25 mg verapamil/kg i.m. or 5 mg lidocaine/kg im prolonged the sleep time induced by the anesthetic agents. Administration of 5 mg verapamil/kg i.m. caused unexpected acute toxicity and mortality. This study suggests that propofol and xylazine + ketamine anesthesia in broilers may be modulated by calcium and sodium channels.

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