• Yujun Cong, Xin Xia, Junqi Liao, Aimei Zhang, Tianrui Zhang, Xiaofeng Cao, Peian Liu, Fei Ma, Xiaogang Tang, Jingyi Chen, Yang Han, Zhaoyao Chen, Wenlei Li, Yuan Zhu, Beibei Yao, and Minghua Wu.
• Department of Neurology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China; Department of Neurology, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China; The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China; Department of Neurology, Rushan Hospital of Traditional Chinese Medicine, Weihai, China.
• World Neurosurg. 2024 Oct 1; 190: e1071e1080e1071-e1080.

BackgroundInflammatory markers for the prognosis of acute ischemic stroke (AIS) with endovascular therapy remain unclear. The purpose of this study was to investigate the association between the systemic inflammatory response index (SIRI) and neutrophil-to-lymphocyte ratio (NLR) with unfavorable functional outcomes at 90-day in individuals of AIS who underwent endovascular therapy.MethodsA total of 128 AIS patients who had endovascular therapy were enrolled from the Nanjing Stroke Registry between September 2019 and November 2022. Peripheral venous blood was collected from patients within 24 h of admission for information on the following parameters: neutrophil count, lymphocyte count, and monocyte count. Then, the SIRI and NLR values were calculated and the association among SIRI, NLR, and modifled Rankin Scale scores 90 days after endovascular therapy was examined via univariate and multivariate logistic analyses. Receiver operating characteristic curves were utilized to determine the best threshold for SIRI and NLR in predicting negative neurological outcomes following endovascular treatment for patients with AIS.ResultsA total of 128 participants were evaluated, among which 50% had unfavorable outcomes. Linear regression analysis showed that the best threshold for SIRI was >1.407 (odds ratio = 1.265; 95% confidence interval, 1.071-1.493; P = 0.006), and for NLR it was >5.347 (odds ratio = 1.088; 95% confidence interval, 1.007-1.175; P = 0.033). These results revealed NLR and SIRI as significant predictors of unfavorable outcomes at 90 days. The area under the curve for SIRI and NLR in predicting 90-day adverse outcomes was 0.643 and 0.609, respectively.ConclusionsHigher SIRI and NLR levels at admission may lead to unfavorable outcomes at 90 days for AIS patients with endovascular therapy.Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

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