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- Di Chen, Lin-Jun Wang, Hong-Lei Li, Fei Feng, Jian-Chun Li, and Liping Liu.
- The First Clinical Medical School of Lanzhou University, Lanzhou, Gansu, P. R. China.
- Medicine (Baltimore). 2024 Aug 16; 103 (33): e38901e38901.
AbstractSeptic cardiomyopathy (SCM) is a severe complication caused by sepsis, resulting in a high mortality rate. The current understanding of the pathogenic mechanism of SCM primarily involves endocardial injury, microcirculation disturbance, mitochondrial dysfunction and fibrosis. Heparanase (HPA), an endo-β-D-glucuronidase, has been implicated in inflammation, immune response, coagulation promotion, microcirculation disturbance, mitochondrial dysfunction and fibrosis. Therefore, it was hypothesized that HPA may play an important role in the pathogenesis of SCM. The present study provides a summary of various pathophysiological changes and mechanisms behind the involvement of HPA in SCM. It also presents a novel perspective on the pathogenic mechanism, diagnosis and treatment of SCM.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.
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