• J. Investig. Med. · Sep 2024

    Review

    EXPRESS: The role of Fusobacterium nucleatum in the pathogenesis of colon cancer.

    • Bo-Young Hong, Ajay Chhaya, Alejandro Robles, Jorge Cervantes, and Sangeeta Tiwari.
    • Dr. Kiran C. Patel College of Allopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA.
    • J. Investig. Med. 2024 Sep 18: 1081558924127782910815589241277829.

    AbstractPreviously, many studies have reported changes in the gut microbiota of patients with colorectal cancer (CRC). While CRC is a well-described disease, the relationship between its development and features of the intestinal microbiome is still being understood. Evidence linking Fusobacterium nucleatum enrichment in colorectal tumor tissue has prompted the elucidation of various molecular mechanisms and tumor-promoting attributes. In this review we highlight various aspects of our understanding of the relationship between the development of CRC and the alteration of intestinal microbiome, focusing specifically on the role of F. nucleatum. As the amount of F. nucleatum DNA in CRC tissue is associated with shorter survival, it may potentially serve as a prognostic biomarker, and most importantly may open the door for a role in CRC treatment.

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