• Hala M El-Sadek, Asmaa A Elmadbouly, and Basma E M Risha.
• Department of Dermatology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt. HalaMohammed.5323@azhar.edu.eg.
• Ir J Med Sci. 2024 Aug 26.

BackgroundVitiligo is an inflammatory, autoimmune disorder. Its pathogenesis is unclear. A neutrophil activation marker (calprotectin) is a protein complex present in many different types of cells and may be used as an indicator of inflammation.AimsThis study is to assess calprotectin levels in non-segmental vitiligo patients and compare them to the severity of the illness to identify potential associations.MethodsThe present inquiry was conducted on thirty non-segmental vitiligo patients and thirty healthy volunteers matched in terms of age and gender. The Vitiligo Area Scoring Index was used to assess the vitiligo severity. Calprotectin levels were measured in serum samples obtained from all participants by Enzyme Linked Immunosorbent Assay.ResultsCompared to controls, non-segmental vitiligo patients had considerably elevated serum calprotectin levels. Additionally, calprotectin levels were shown to have a significant positive association with disease severity (r = 0.833, P = 0.000).ConclusionsElevated levels of serum calprotectin in non-segmental vitiligo patients relative to healthy individuals with high sensitivity indicated that it may have a role in the vitiligo pathophysiology and can act as a marker for disease monitoring.© 2024. The Author(s).

4 keywords...

hide…