• Medicine · Aug 2024

    Case Reports

    Successful corticosteroid therapy for severe liver injury secondary to herbal traditional Chinese medicine, Mega Defends X, assessed for causality by the updated RUCAM: A case report.

    • Lu Chai, Ran Wang, Rolf Teschke, Shenghao Jin, Jiao Deng, and Xingshun Qi.
    • Department of Gastroenterology, Liver Cirrhosis Study Group, General Hospital of Northern Theater Command (Teaching Hospital of Shenyang Pharmaceutical University), Shenyang, China.
    • Medicine (Baltimore). 2024 Aug 23; 103 (34): e39439e39439.

    RationaleIn China, herbal traditional Chinese medicine products are readily obtained without any requirement of prescription and widely used in real life, thereby increasing the incidence of their related herb-induced liver injury (HILI). However, the diagnosis of HILI is still challenging because its clinical manifestations are variable due to lack of any specific biomarkers. Misdiagnosis and inappropriate treatment may result in the progression of HILI.Patient ConcernsA 55-year-old female patient was admitted to the hospital due to progressive jaundice.DiagnosesThe diagnoses of HILI secondary to Mega Defends X, an herbal traditional Chinese medicine product, for which the score was 9 based on the updated Roussel Uclaf Causality Assessment Method of 2016.InterventionsThe patient received corticosteroid with a stepwise dosage reduction.OutcomesThe liver injury significantly improved by corticosteroid treatment.LessonsCorticosteroids should be potentially effective and safe in patients with severe HILI.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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