• S J H Heines, S A M de Jongh, de JonghF H CFHC0000-0002-6052-7504Department of Pulmonology, Medisch Spectrum Twente, Enschede, The Netherlands., R P J Segers, K M H Gilissen, van der HorstI C CICC0000-0003-3891-8522Department of Intensive Care, Maastricht University Medical Center+, P. Debyelaan 25, P.O. Box 5800, Maastricht, 6202, AZ, The Netherlands.Cardiovascular Research Institute Maastricht (CARIM), Maastricht University,, B C T van Bussel, and BergmansD C J JDCJJ0000-0002-4224-6426Department of Intensive Care, Maastricht University Medical Center+, P. Debyelaan 25, P.O. Box 5800, Maastricht, 6202, AZ, The Netherlands.School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastri.
• Department of Intensive Care, Maastricht University Medical Center+, P. Debyelaan 25, P.O. Box 5800, Maastricht, 6202, AZ, The Netherlands. S.heines@mumc.nl.
• J Clin Monit Comput. 2024 Aug 28.

AbstractThere is no universally accepted method for positive end expiratory pressure (PEEP) titration approach for patients on spontaneous mechanical ventilation (SMV). Electrical impedance tomography (EIT) guided PEEP-titration has shown promising results in controlled mechanical ventilation (CMV), current implemented algorithm for PEEP titration (based on regional compliance measurements) is not applicable in SMV. Regional peak flow (RPF, defined as the highest inspiratory flow rate based on EIT at a certain PEEP level) is a new method for quantifying regional lung mechanics designed for SMV. The objective is to study whether RPF by EIT is a feasible method for PEEP titration during SMV. Single EIT measurements were performed in COVID-19 ARDS patients on SMV. Clinical (i.e., tidal volume, airway occlusion pressure, end-tidal CO2) and mechanical (cyclic alveolar recruitment, recruitment, cumulative overdistension (OD), cumulative collapse (CL), pendelluft, and PEEP) outcomes were determined by EIT at several pre-defined PEEP thresholds (1-10% CL and the intersection of the OD and CL curves) and outcomes at all thresholds were compared to the outcomes at baseline PEEP. In total, 25 patients were included. No significant and clinically relevant differences were found between thresholds for tidal volume, end-tidal CO2, and P0.1 compared to baseline PEEP; cyclic alveolar recruitment rates changed by -3.9% to -37.9% across thresholds; recruitment rates ranged from - 49.4% to + 79.2%; cumulative overdistension changed from - 75.9% to + 373.4% across thresholds; cumulative collapse changed from 0% to -94.3%; PEEP levels from 10 up to 14 cmH2O were observed across thresholds compared to baseline PEEP of 10 cmH2O. A threshold of approximately 5% cumulative collapse yields the optimum compromise between all clinical and mechanical outcomes. EIT-guided PEEP titration by the RPF approach is feasible and is linked to improved overall lung mechanics) during SMV using a threshold of approximately 5% CL. However, the long-term clinical safety and effect of this approach remain to be determined.© 2024. The Author(s).

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