Diagnostic and therapeutic management of Clostridioides

Medicina clinica · Sep 2024

Review

Diagnostic and therapeutic management of Clostridioides difficile infection.

A review of the diagnostic and therapeutic management algorithm of the pathogen Clostridioides difficile for daily practice is presented. Its diagnosis, in any unformed stool sample sent to the laboratory, is based on a two-step algorithm, with demonstration of the pathogen by means of its enzyme glutamate dehydrogenase by immunoassay and subsequent PCR (polymerase chain reaction) of its toxin. The mainstay of step therapy, reserved for symptomatic patients, is fidaxomicin, over vancomycin. ⋯ Emerging therapies, such as faecal microbiota transplantation or the antibody bezlotoxumab, are gaining importance in patients with risk factors or relapses. Surgery is indicated in patients with worse prognosis and complications. Prevention is essential, based on vigilance and contact precautions, in addition to the elimination of spores from the environment.

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- Miguel Ángel López Zúñiga, Antonio Sánchez Cabello, and Miguel Ángel López Ruz.
- Unidad de Enfermedades Infecciosas, Hospital Virgen de las Nieves, Granada, España. Electronic address: miguelangellopezzuniga@gmail.com.
- Med Clin (Barc). 2024 Sep 12.
AbstractA review of the diagnostic and therapeutic management algorithm of the pathogen Clostridioides difficile for daily practice is presented. Its diagnosis, in any unformed stool sample sent to the laboratory, is based on a two-step algorithm, with demonstration of the pathogen by means of its enzyme glutamate dehydrogenase by immunoassay and subsequent PCR (polymerase chain reaction) of its toxin. The mainstay of step therapy, reserved for symptomatic patients, is fidaxomicin, over vancomycin. Metronidazole is not an adequate treatment. Emerging therapies, such as faecal microbiota transplantation or the antibody bezlotoxumab, are gaining importance in patients with risk factors or relapses. Surgery is indicated in patients with worse prognosis and complications. Prevention is essential, based on vigilance and contact precautions, in addition to the elimination of spores from the environment.Copyright © 2024 Elsevier España, S.L.U. All rights reserved.

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Diagnostic and therapeutic management of Clostridioides difficile infection.

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