• Micah K de Valle, Cooper Stevenson, Michael Adkison, Christy Delaune, Nicholas Defilippis, and Shobana Murugan.
• From the John Sealy School of Medicine, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas.
• A A Pract. 2024 Sep 1; 18 (9): e01833e01833.

AbstractHereditary angioedema (HAE) is a rare disorder due to C1 esterase inhibitor deficiency, causing recurrent swelling. Pregnancy can exacerbate HAE due to estrogen fluctuations alongside peripartum stress and trauma. We present a pregnant patient with HAE who underwent induction of labor and vaginal delivery with neuraxial anesthesia. Management included C1-inhibitor prophylaxis, 48 hours of postpartum monitoring, and a self-treatment plan at discharge. Angioedema prevention involves timely anesthesia consultation, accessible emergency airway equipment, early neuraxial anesthesia, planned vaginal delivery, and 48 to 72 hours of close postpartum monitoring. Readily available C1-inhibitor and a multidisciplinary approach with these recommendations are crucial for peripartum management.Copyright © 2024 International Anesthesia Research Society.

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