• Jingyi Wang, Qifan Bian, Xiaoqing Chen, Yue Feng, Lantian Zhang, and Peng Chen.
• Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, China.
• Medicine (Baltimore). 2024 Sep 6; 103 (36): e39574e39574.

AbstractPerioperative inflammatory responses are a series of endogenous immune responses produced by the body following surgical trauma. Excessive inflammatory response weakens the body's ability to repair surgical trauma and reduces the body's defense against the invasion of harmful factors, leading to a series of complications, such as infections, pain, and organ damage, which prolong the length of hospitalization and increase the risk of death. Lidocaine is a classical local anesthetic widely used in clinical practice because of its local anesthetic and antiarrhythmic effects. Several recent studies have shown that lidocaine modulates the body's inflammatory response, and that its anti-inflammatory properties can lead to analgesia, organ protection, and improved postoperative recovery. In this paper, we introduce the mechanism of the modulating effect of lidocaine on the perioperative inflammatory response and its clinical application, to provide a reference for the clinical prevention and treatment of the perioperative inflammatory response.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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