• Elisa Díaz-Grijuela, Agustín Hernández, Claudia Caballero, Roberto Fernandez, Raquel Urtasun, Marina Gulak, Egoitz Astigarraga, Miguel Barajas, and Gabriel Barreda-Gómez.
• Betternostics SL, 31110 Noáin, Spain.
• Medicina (Kaunas). 2024 Jul 25; 60 (8).

AbstractRecent advancements in mass spectrometry have significantly enhanced our understanding of complex lipid profiles, opening new avenues for oncological diagnostics. This review highlights the importance of lipidomics in the comprehension of certain metabolic pathways and its potential for the detection and characterization of various cancers, in particular melanoma. Through detailed case studies, we demonstrate how lipidomic analysis has led to significant breakthroughs in the identification and understanding of cancer types and its potential for detecting unique biomarkers that are instrumental in its diagnosis. Additionally, this review addresses the technical challenges and future perspectives of these methodologies, including their potential expansion and refinement for clinical applications. The discussion underscores the critical role of lipidomic profiling in advancing cancer diagnostics, proposing a new paradigm in how we approach this devastating disease, with particular emphasis on its application in comparative oncology.

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