• Supranee Niruthisard, Thewarug Werawataganon, Pavena Bunburaphong, Montson Ussawanophakiat, Chuthayuth Wongsakornchaikul, and Kusonsi Toleb.
• Department of Anesthesiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. drsupranee@hotmail.com
• Anesth. Analg. 2007 Sep 1;105(3):822-4.

BackgroundThe addition of parecoxib to intrathecal morphine and bupivacaine may improve analgesia and reduce morphine's opioid-related side effects.MethodsIn this prospective, double-blind, randomized, placebo-controlled trial, total abdominal hysterectomy patients received either IV normal saline or parecoxib 40 mg before receiving intrathecal bupivacaine and morphine 0.2 mg. Twelve hours later, this administration was repeated. Patients were observed for 48 h.ResultsThe addition of parecoxib to intrathecal morphine and bupivacaine significantly reduced cumulative morphine consumption, Visual Analog Pain scores, and increased patient satisfaction for 24 h postoperatively without an obvious decrease of adverse side effects.ConclusionPerioperative parecoxib enhanced the postoperative analgesia of intrathecal morphine and bupivacaine and improved patient satisfaction.

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