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- Yoshihiro Tokunaga, Yukinori Nakamura, Taishi Ando, Kensaku Katsuki, Kohei Sakai, Yuka Fujioka, Shota Nono, Takahiro Sasaki, Kaoru Yamamoto, Masaru Akiyama, Fumihiro Kawakami, Toru Kawakami, Fumihiro Ishida, Yasuharu Ohta, and Toshiaki Yujiri.
- Third Department of Internal Medicine, Yamaguchi University Hospital, Japan.
- Intern. Med. 2024 Aug 28.
AbstractA 64-year-old woman presented with agranulocytosis, anemia, and bacteremia, leading to a diagnosis of T-cell large granular lymphocytic leukemia (T-LGLL). A molecular analysis identified a signal transducer and activator of transcription 3 (STAT3) Y640F variant. Initial treatment with cyclophosphamide and prednisolone did not improve her condition, but serious infections were observed. The patient underwent cord blood transplantation (CBT) after preconditioning with fludarabine, busulfan, and total body irradiation, yielding a STAT3 Y640F variant disappearance, based on allele-specific quantitative polymerase chain reaction (AS-qPCR). In this case, CBT is a promising refractory T-LGLL treatment option, and the STAT3 Y640F variant AS-qPCR is a T-LGLL activity marker.
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