• Internal medicine · Aug 2024

    A Case of TAFRO-like Symptoms in a Sjögren's Syndrome Patient with HTLV-1 Infection.

    • Takuya Masuda, Takeshi Suzuki, Miho Ohshima, Akitake Suzuki, Nobuyoshi Minemura, and Hiroyoshi Nakajima.
    • Department General Internal Medicine, Mitsui Memorial Hospital, Japan.
    • Intern. Med. 2024 Aug 28.

    AbstractA 58-year-old woman was admitted to our hospital with anasarca and generalized lymphadenopathy. Laboratory data showed serum Cr 1.48 mg/dL, CRP 2.38 mg/dL, PLT 102,000/μL, and anti-SS-A antibodies (SS-A-ab). A lymph node biopsy revealed a regressed germinal center and hypervascularization in the interfollicular area. The patient was diagnosed with TAFRO-like symptoms occurring with Sjögren's syndrome and HTLV-1 infection, and 80 mg of methylprednisolone and tocilizumab 8 mg/kg biweekly were initiated. Her body weight decreased from 59.4 to 41 kg, and pleural effusion disappeared 8 weeks later. This case suggests that TAFRO-like symptoms may occur in patients with Sjögren's syndrome with HTLV-1 infection.

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