• Internal medicine · Sep 2024

    Effectiveness of Additional Immunosuppressive Drugs for Corticosteroid-refractory Immune Checkpoint Inhibitor-induced Myocarditis: Two Case Reports.

    • Hiroyuki Sakaguchi, Shigeki Nanjo, Shigeki Sato, Hiroshi Kotani, Akihiro Nishiyama, Kaname Yamashita, Koushiro Ohtsubo, Chiaki Suzuki, Masaya Shimojima, Seiji Yano, and Shinji Takeuchi.
    • Department of Medical Oncology, Kanazawa University Hospital, Japan.
    • Intern. Med. 2024 Sep 4.

    AbstractImmune checkpoint inhibitors (ICIs) improve the outcomes of several types of cancer. However, they are also associated with various immune-related adverse events including myocarditis. ICI-induced myocarditis is a rare, potentially life-threatening adverse event. We herein report two cases of corticosteroid-refractory ICI-induced myocarditis. In both cases, additional immunosuppressive therapies, such as intravenous immunoglobulin and tacrolimus, successfully resolved myocarditis. Given the corticosteroid-refractory nature of these cases, we suggest that prompt addition of other immunosuppressive drugs to corticosteroid therapy should be considered in the treatment of ICI-induced myocarditis.

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