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- Lisa Yamasaki, Yutaro Akiyama, Keigo Ueno, Yasutaka Hoshino, Minoru Nagi, Nobuko Nakayama, Masahiro Abe, Yoshitsugu Miyazaki, Hiroyuki Gatanaga, and Koji Watanabe.
- Center Hospital of the National Center for Global Health and Medicine, Japan.
- Intern. Med. 2024 Sep 4.
AbstractHistoplasmosis is caused by Histoplasma capsulatum and is prevalent in areas of the world where H. capsulatum is endemic. We herein report a patient diagnosed with HIV-1 who developed histoplasmosis from a non-H. capsulatum endemic area who experienced severe hemophagocytic syndrome due to a delayed diagnosis. The patient's symptoms emerged four years after residing in regions with a high histoplasmosis prevalence. The unrestricted administration of antifungal medication for oral candidiasis delayed the diagnosis because it improved the patient's condition. This case underscores the importance of prudent antifungal drug use in undiagnosed disseminated conditions and evaluating the travel history going back several years to facilitate a diagnosis.
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