• Internal medicine · Nov 2024

    Case Reports

    Diagnosis of Graves' Disease During Treatment for Subacute Thyroiditis: A Case Report.

    • Misa Yuuki, Kotaro Kurasaki, Mariko Murata, Mizusa Matsuda, Yusuke Hata, Kyohei Horiguchi, Kumiko Hamano, and Yoshio Nagai.
    • Division of Diabetes and Endocrinology, Kanto Rosai Hospital, Japan.
    • Intern. Med. 2024 Nov 1; 63 (21): 294929522949-2952.

    AbstractThe co-occurrence of subacute thyroiditis (SAT) and Graves' disease (GD) is rare. A 62-year-old Japanese man presented with shifting neck pain and elevated thyroid hormone level. The patient tested positive for thyroid-stimulating hormone receptor antibodies. Additionally, thyroid hormone levels did not decrease during treatment with prednisolone for SAT. Consequently, concurrent GD was suspected, and diagnostic assistance was obtained by confirming increased uptake on 99mTechnetium thyroid scintigraphy. A genetic analysis of human leukocyte antigen (HLA) revealed genotypes associated with susceptibility to SAT (HLA-B*35:01) and GD (HLA-DPB1*05:01). Furthermore, the possibility of coronavirus disease 2019 as a related environmental factor cannot be ruled out in this case.

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