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- Kakeru Otomo, Masashi Fujita, Ryoji Sekine, Hidenori Sato, Naoto Abe, Tatsuro Sugaya, Chiharu Watanabe, Yosuke Takahata, Manabu Hayashi, Kazumichi Abe, Atsushi Takahashi, and Hiromasa Ohira.
- Department of Gastroenterology, Fukushima Medical University School of Medicine, Japan.
- Intern. Med. 2024 Sep 11.
AbstractA 65-year-old man treated with atezolizumab plus bevacizumab for hepatocellular carcinoma was admitted to our hospital with a fever, difficulty in moving, and aphasia. The patient became comatose immediately after admission. Imaging and cerebral fluid tests revealed no evidence of malignancy or infection. A diagnosis of atezolizumab-induced encephalitis was made, and steroid pulse therapy was initiated on admission, immediately after which the patient regained consciousness and was able to talk and walk. He was discharged with slight paralysis of his legs and was able to resume chemotherapy. An early diagnosis and treatment are required to improve the prognosis of encephalitis.
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