• Patricia Rubí-González, Karla Muáoz-Guzmán, Mariela Gatica-Saavedra, Gonzalo Navarrete Ríos, Marcela Rocha González, Pablo Fabregas-Soto, and Giuliana Maccarini-Llorens.
• Departamento de Psiquiatría y Salud Mental, Facultad de Medicina, Universidad de Concepción, Concepción, Chile.
• Rev Med Chil. 2023 Dec 1; 151 (12): 162316301623-1630.

UnlabelledLithium is a mood stabilizer recommended by most clinical guidelines as the gold standard to prevent relapses in the treatment of Bipolar Affective Disorder. It is highly effective, but unfortunately, it causes adverse effects at several levels, including the skin.AimTo review the frequency, presentation, evolution, and management of adverse dermatologic effects caused by this drug.MethodsWe performed a narrative review using Scielo, Web of Science (WoS), and Google Scholar search engines, using keywords in Spanish and English.ResultsThe skin presentations that appear most frequently are the progression of previously existing or newly diagnosed psoriasis, alopecia, acne, follicular inflammation, and maculopapular eruptions.ConclusionsLithium produces and/or exacerbates a series of dermatological conditions of different severity, even at therapeutic levels, which are not usually severe but, even so, should not be underestimated since it can affect adherence to the drug.

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