• N. Engl. J. Med. · Mar 1978

    The diagnostic importance of the normal finding.

    • G A Gorry, S G Pauker, and W B Schwartz.
    • N. Engl. J. Med. 1978 Mar 2; 298 (9): 486489486-9.

    AbstractWhen a diagnostic test is reported as normal, the clinician generally uses it only to rule out certain diseases. However, if properly interpreted, the normal value may help to differentiate among diagnoses that yield normal results with different frequencies. A simple method permits the extraction of such information. The physician estimates the probability of various diagnoses and then combines these estimates with the anticipated frequency of negative results for each disease under consideration.

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