• Behzad Babapour, Hossein Doustkami, Leli Avesta, Peyman Kiamehr, and Mohammad Reza Aslani.
• Department of Cardiology, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
• J Res Med Sci. 2024 Jan 1; 29: 2626.

BackgroundApelin is one of the endogenous peptides that play a key role in the homeostasis of cardiovascular diseases. The purpose of the current study was to evaluate the correlation between apelin levels and epicardial fat thickness (EFT) in patients with stable angina and acute myocardial infarction (AMI).Materials And MethodsIn a case-control study, 90 patients nominated for angiography were enrolled in the study and divided into three groups: healthy subjects without angiographic findings (Con), stable angina pectoris group (SAP), and acute AMI group. Data collected from all subjects included biochemical, echocardiographic, and angiographical parameters. The Gensini score analyzed the severity of coronary artery disease (CAD).ResultsA decrease in adjusted apelin levels was evident in the AMI and SAP groups compared with healthy individuals (for both P < 0.001), especially in the AMI group. In addition, a detectable negative association was identified between apelin and Gensini score (r = -0.288, P = 0.006), Ck-MB (r = -0.300, P = 0.004), EFT (r = -0.300, P = 0.004), and troponin-T (r = -0.288, P = 0.006).ConclusionMyocardial injury in patients with CAD appears to play a significant role in apelin concentration independent of the role of adipose tissue, which requires further studies.Copyright: © 2024 Journal of Research in Medical Sciences.

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