• Taner Abdullah, Hürü Ceren Gökduman, İşbara Alp Enişte, İlyas Kudaş, Achmet Ali, Erdem Kınacı, İlgin Özden, and Gümüş ÖzcanFundaF.
• From the Department of Anaesthesiology, Istanbul Başakşehir Çam&Sakura City Hospital (TA, HCG, İAE, FGÖ), Department of General Surgery, Istanbul Başakşehir Çam&Sakura City Hospital (İK), Department of Anaesthesiology, Istanbul Medical Faculty, Istanbul University (AA), and Liver Transplantation & Hepatopancreatobiliary Surgery Unit, Department of General Surgery, Istanbul Başakşehir Çam&Sakura City Hospital (EK, İÖ).
• Eur J Anaesthesiol. 2024 Sep 12.

BackgroundMyocardial injury after noncardiac surgery (MINS) frequently complicates the peri-operative period and is associated with increased mortality.ObjectivesWe hypothesised that cardiac index (CI) based haemodynamic management reduces peri-operative high-sensitive troponin-T (hsTnT) elevation and MINS incidence in patients undergoing hepatic/pancreatic surgery compared to mean arterial pressure.DesignA randomised controlled study.SettingA single-centre study conducted in a university-affiliated tertiary hospital between June 2022 and March 2023.PatientsNinety-one patients, who were ≥ 65 years old or ≥ 45 years old with a history of at least one cardiac risk factor were randomised to either mean arterial pressure (MAP) based (n = 45) or CI-based (n = 46) management groups, and completed the study.InterventionsIn group-MAP, patients received fluid boluses and/or a noradrenaline infusion to maintain MAP above the predefined threshold. In group-CI, patients received fluid boluses and/or dobutamine infusion to keep CI above the predefined threshold. When a low MAP was observed despite a normal CI, a noradrenaline infusion was started.Main Outcome MeasuresThe primary outcome was peri-operative hsTnT elevation. The secondary outcomes were MINS incidence and 90-day mortality.ResultsThe median absolute troponin elevation was 4.3 ng l-1 (95% CI 3.4 to 6) for the CI-based group, and 9.4 ng l-1 (95% CI 7.7 to 12.7) for the MAP-based group (median difference: 5.1 ng l-1, 95% CI 3 to 7; P < 0.001). MINS occurred in 8 (17.4%) patients in the CI-based group and 17 (37.8%) patients in the MAP-based group (relative risk: 0.46, 95% CI: 0.22 to 0.96; P = 0.029). Two patients in group-MAP died from cardiovascular-related causes. One patient in group-CI and two in group-MAP died from sepsis-related complications (for all-cause mortality: χ2 = 1.98, P = 0.16). MAP-AUC and CI-AUC values of the CI- and MAP-based groups were 147 vs. 179 min × mmHg (P = 0.85) and 8.4 vs. 43.2 l m-2 min-1 × min (P < 0.001), respectively.ConclusionsCI-based haemodynamic management assures sufficient flow and consequently is associated with peri-operative hsTnT elevation and the incidence of MINS compared to MAP.Trial RegistrationClinicaltrials.gov identifier: NCT05391087.Copyright © 2024 European Society of Anaesthesiology and Intensive Care. Unauthorized reproduction of this article is prohibited.

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