• Eur. J. Intern. Med. · Dec 2024

    Observational Study

    Carotid plaque offsets sex-related differences in cardiovascular risk of young hypertensive patients.

    • Costantino Mancusi, Christian Basile, Eva Gerdts, Ilaria Fucile, Maria Virginia Manzi, Maria Lembo, Daniela Pacella, Giuseppe Giugliano, Grazia Canciello, Raffaele Piccolo, Alessandra Spinelli, Carmine Morisco, Nicola De Luca, Bruno Trimarco, Giovanni de Simone, Eduardo Bossone, Raffaele Izzo, Maria Angela Losi, and Giovanni Esposito.
    • Hypertension Research Center and Department of Advanced Biomedical Science, Federico II University, Naples, Italy.
    • Eur. J. Intern. Med. 2024 Dec 1; 130: 137143137-143.

    BackgroundWomen have a lower risk for cardiovascular (CV) disease compared to men. Whether this difference is influenced by the presence of hypertension-mediated organ damage is unknown.ObjectiveTo assess whether the presence of carotid plaque (CP) impacts the sex difference in risk for CV events in treated hypertensive patients.MethodsFrom the Campania Salute Network Registry 2419 women and men <51 years of age with treated hypertension and free from prevalent CV disease were included. The presence of CP was identified by Doppler ultrasound (intima-media thickness≥1.5 mm). The primary outcome was a composite of fatal and non-fatal stroke or myocardial infarction, sudden death, TIA, myocardial revascularization, de novo angina, and atrial fibrillation.ResultsAmong patients without CP at baseline (n = 1807), women were older, with higher systolic blood pressure, serum cholesterol level and prevalence of LVH but lower serum triglycerides and eGFR, compared to men (all p < 0.001). Among patients with CP (n = 612), women were older, used higher number of antihypertensive drugs, had higher serum cholesterol level and prevalence of left ventricular hypertrophy (LVH), but had lower serum triglycerides and eGFR compared to men (all p < 0.001). During follow-up, women without CP had a lower risk for CV disease than men (hazard ratio, HR, 0.51, 95 % confidence intervals, CI, 0.27-0.99, p = 0.04) after accounting for cardiovascular risk factors, LVH, and antihypertensive treatment. In contrast, among patients with CP, women had similar risk for CV disease compared with men (HR 1.3, 95 % CI, 0.59-2.9, p = 0.48).ConclusionsOur findings suggest that the presence of CP in young patients with treated hypertension offsets the CV disease protection in women.Trial RegistrationNCT02211365.Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…

What will the 'Medical Journal of You' look like?

Start your free 21 day trial now.

We guarantee your privacy. Your email address will not be shared.