• Yun Chen, Longgang Zhao, Su Yon Jung, Margaret S Pichardo, Melissa Lopez-Pentecost, Thomas E Rohan, Nazmus Saquib, Yangbo Sun, Fred K Tabung, Tongzhang Zheng, Jean Wactawski-Wende, JoAnn E Manson, Marian L Neuhouser, and Xuehong Zhang.
• Yale School of Nursing, Orange, Connecticut, USA.
• J. Intern. Med. 2024 Nov 1; 296 (5): 410421410-421.

BackgroundWe aimed to prospectively evaluate the association between a diabetes risk reduction diet (DRRD) score and the risk of liver cancer development and chronic liver disease-specific mortality.MethodsWe included 98,786 postmenopausal women from the Women's Health Initiative-Observational Study and the usual diet arm of the Diet Modification trial. The DRRD score was derived from eight factors: high intakes of dietary fiber, coffee, nuts, polyunsaturated fatty acids, low intakes of red and processed meat, foods with high glycemic index, sugar-sweetened beverages (SSBs), and trans fat based on a validated Food-Frequency Questionnaire administered at baseline (1993-1998). Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) for liver cancer incidence and chronic liver disease mortality were estimated using Cox proportional hazards regression models.Results And ConclusionAfter a median follow-up of 22.0 years, 216 incident liver cancer cases and 153 chronic liver disease deaths were confirmed. A higher DRRD score was significantly associated with a reduced risk of developing liver cancer (HRTertile 3 vs. Tertile 1 = 0.69; 95% CI: 0.49-0.97; Ptrend = 0.03) and chronic liver disease mortality (HRT3 vs. T1 = 0.54; 95% CI: 0.35-0.82; Ptrend = 0.003). We further found inverse associations with dietary fiber and coffee, and positive associations with dietary glycemic index, SSBs, and trans fat. A higher DRRD score was associated with reduced risk of developing liver cancer and chronic liver disease mortality among postmenopausal women.© 2024 The Association for the Publication of the Journal of Internal Medicine.

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