• Simeone Andrulli, Antonietta Gigante, Michele Rossini, Pierluigi D'Angio', Gisella Vischini, Franca Luchetta, Filippo Aucella, Giovanni Valsecchi, Barbara Infante, Maria Giovanna Vario, Domenico Giannese, Antonio Granata, Elisabetta Moggia, Guido Gembillo, Rosario Cianci, Mario Bonomini, Flavia Manenti, Roberta Lazzarin, Brigida Di Renzo, Fulvia Zanchelli, Maurizio Garozzo, Massimo Manes, Yuri Battaglia, Raffaela Sciri, FabritiisMarco DeMNephrology and Dialysis Unit, Morgagni-Pierantoni Hospital, Forlì, Italy., Marco Quaglia, CavoliGioacchino LiGLDepartment of Nephrology Dialysis Renal Transplantation, Civic Hospital, Palermo, Italy., Enrica Gintoli, Maria Maddalena Conte, Maurizio Borzumati, Luisa Benozzi, Giovanna Pasquariello, Giovanni Andrulli, Marco Leoni, Giuseppe Seminara, Valentina Corbani, Gianmarco Sabiu, Arcangelo Di Maggio, Rosa Maria Pollastro, Loreto Gesualdo, and ITA-KID-BIOPSY Group.
• Associazione Italiana Ricercare per Curare ODV ETS (AIRpC), Lecco, Italy.
• Intern Emerg Med. 2024 Sep 13.

AbstractThe evaluation of estimated GFR (eGFR) is a pivotal staging step in patients with chronic kidney disease (CKD), and renal ultrasound plays an important role in diagnosis, prognosis and progression of CKD. The interaction between histopathological diagnosis and ultrasound parameters in eGFR determination has not been fully investigated yet. The study examined the results of native kidney biopsies performed in 48 Italian centers between 2012 and 2020. The primary goal was if and how the histopathological diagnosis influences the relationship between ultrasound parameters and eGFR. After exclusion of children, patients with acute kidney injury and patients without measure of kidney length or parenchymal thickness, 2795 patients have been selected for analysis. The median values were 52 years for patient age, 11 cm for bipolar kidney diameter, 16 mm for parenchymal thickness, 2.5 g/day for proteinuria and 70 ml/min/1.73 m2 for eGFR. The bipolar kidney diameter and the parenchymal thickness were directly related with eGFR values (R square 0.064). Diabetes and proteinuria were associated with a consistent reduction of eGFR, improving the adjusted R square up to 0.100. Addition of histopathological diagnosis in the model increased the adjusted R square to 0.216. There is a significant interaction between histopathological diagnosis and longitudinal kidney diameter (P 0.006). Renal bipolar length and parenchymal thickness are directly related with eGFR. The magnitude of proteinuria and histopathological kidney diagnosis are associated with eGFR. The relationship between kidney length and the level of eGFR depends on the nature of the kidney disease.© 2024. The Author(s).

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