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- Zhibin Wang, Wenzhao Zhang, Linlin Chen, Xin Lu, and Ye Tu.
- Department of Critical Care Medicine, School of Anesthesiology, Naval Medical University, Shanghai, 200433, China. methyl@smmu.edu.cn.
- Crit Care. 2024 Sep 20; 28 (1): 315315.
AbstractThis narrative review provides an overview of the evolving significance of lymphopenia in sepsis, emphasizing its critical function in this complex and heterogeneous disease. We describe the causal relationship of lymphopenia with clinical outcomes, sustained immunosuppression, and its correlation with sepsis prediction markers and therapeutic targets. The primary mechanisms of septic lymphopenia are highlighted. In addition, the paper summarizes various attempts to treat lymphopenia and highlights the practical significance of promoting lymphocyte proliferation as the next research direction.© 2024. The Author(s).
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