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- Ayako Togawa, Masayuki Ueno, Mari Yamaoka, Kensuke Takada, Shinichi Nishina, Yuki Ikeda, Yosuke Uenishi, Ayako Hata, Toshifumi Mano, Toshikazu Moriwaki, Hirokazu Mouri, and Motowo Mizuno.
- Department of Gastroenterology and Hepatology, Kurashiki Central Hospital, Japan.
- Intern. Med. 2024 Sep 27.
AbstractWe herein report a patient with Lynch-like syndrome in whom a brain tumor (glioblastoma) developed after repeated resection of colorectal cancer. The patient had a significant family history of cancer. Immunohistochemical expression of mismatch repair proteins was decreased in both brain and colon tumors, but no pathogenic variant of the related genes was detected. Although brain tumors occasionally develop in Lynch syndrome, they have not been reported in cases of Lynch-like syndrome. This first report of Lynch-like syndrome with the development of glioblastoma suggests the need for further investigation on the surveillance of brain tumors in patients with this syndrome.
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