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J. Thorac. Cardiovasc. Surg. · Sep 2024
Long-Term Enlargement of the Neo-Aortic Root and Aortic Arch Following Arch Reconstruction in Hypoplastic Left Heart Syndrome.
- Carmen Lopez Leiva, Devin Chetan, Ankavipar Saprungruang, Steve FanChun-PoCPTed Rogers Centre for Heart Research, University Health Network., Marisa Signorile, Olivier Villemain, Vitor C Guerra, Christopher Z Lam, Mike Seed, Christoph Haller, David J Barron, Osami Honjo, and Shi-Joon Yoo.
- Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick Children; Department of Pediatrics, University of Toronto; Hospital Dr. Sótero del Rio. SSMSO. Santiago, Chile.
- J. Thorac. Cardiovasc. Surg. 2024 Sep 23.
BackgroundLong-term enlargement of the aortic arch after aortic arch reconstruction (AAR) in hypoplastic left heart syndrome (HLHS) is not well described.MethodsAortic arch measurements for 50 patients with HLHS who achieved Fontan completion were converted to Pediatric Heart Network z-scores. Dimensions were assessed using linear mixed models and differences among time points were evaluated with F-tests. Sub-analysis was conducted comparing Norwood (n=36) vs hybrid (n=14) strategies.ResultsMedian time to last imaging was 6.4 (IQR, 3.5-11.3) years. Prior to intervention, the main pulmonary artery was dilated whereas the ascending aorta (AA), transverse arch (TA), and isthmus (ISTH) were hypoplastic. With AAR, there were expected increases in all arch z-scores. The aortic arch continued to dilate after AAR reaching peak values at 7 months [Neo-Aortic Complex (NAC): z= 6.9 (5.6-8.0)] or 12 months following stage I [AAo: z=6.1 (2.9-8.3); TA: z=4.7 (3.0-5.9)]. Following peak values, there was a gradual decline in z-scores with most components still at least mildly dilated at 16 years [NAC: z=3.2 (3.1-3.9), AAo: z=3.9 (3.3-4.2); TA: z=3.1 (2.5-3.7)] with abrupt calibre change at ISTH: z= -0.8 (-1.1- -0.3)]. Norwood and hybrid strategies showed similar enlargement profiles after 7 months of age.ConclusionsNeo-aortic root and aortic arch in HLHS are enlarged early after AAR and continue to enlarge out of proportion to normal controls until 12 months of age, with gradual decline in enlargement up to adolescence. Further work should focus on modifiable surgical factors which may prove important to optimize arch growth and geometry.Copyright © 2024. Published by Elsevier Inc.
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