• Gavin C Touponse, Guan Li, Jesse W Tai, Adrian J Rodrigues, Monica Granucci, Georgiana Burnside, Hriday P Bhambhvani, Summer S Han, Hanlee P Ji, and Melanie Hayden Gephart.
• Department of Neurosurgery, Stanford University School of Medicine, Stanford, California. Electronic address: gtoupon@stanford.edu.
• World Neurosurg. 2024 Sep 23.

PurposePatients with brain metastases (BrM) from esophageal cancer have poor prognosis, the incidence of which is expected to rise due to improved survival from the primary tumor and increased neuroimaging. We aimed to identify patient and esophageal cancer characteristics associated with shorter survival in patients with BrM and, secondly, to compare the prognosis of patients with HER2 overexpression.MethodsWe retrospectively reviewed patients with BrM from esophageal cancer at a single institution from 2008-2021. We collected patient demographics, primary tumor and BrM characteristics, and treatment. Our primary outcome was median survival from the time of BrM.ResultsThe median age at primary diagnosis was 66.5 years and 86% were male. Of the 49 patients, 71% had adenocarcinoma, 20% squamous cell carcinoma and 8% other. 71% of patients presented with stage III or IV disease, including 16% with synchronous primary and BrM. The median time to BrM was 10.1 months (IQR 1.7-22.8) and the median survival from BrM was 8.4 months (95%CI 4.8-16.8). On multivariable analysis, treatment with stereotactic radiosurgery (HR=0.19;p=0.04), surgical resection (HR 0.24;p=0.03) and immunotherapy (HR 0.19;p=0.04) were associated with increased survival while KPS ≤70 (HR=13.2;p<0.001) was associated with decreased survival. HER2 overexpression was found in 22% of patients, but we noted no survival difference (5.2 months HER2+ versus 9.8 months HER2neg;p=0.95).ConclusionThe median survival from esophageal-to-brain metastasis was 8.4 months. Patients with a single lesion, KPS score >70, and treatment with surgical resection was correlated with improved survival. Further, HER2+ patients had distinct patient and BrM characteristics.Copyright © 2024. Published by Elsevier Inc.

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